Technology
Expertise
We specialize in harnessing cutting-edge spatial technologies to uncover and address complex biological questions. Our capabilities include identifying individual cells and their proximities to cells of interest, clustering and classifying cell types within tissues, and mapping their gene expression profiles.
Our work spans a broad spectrum of tissues, soft and hard, paraffin-fixed or frozen, human, murine, and beyond. If you are interested in exploring the possibilities of spatial biology in your research, we welcome you to connect with us and discuss potential collaborations.
Equipment & Service
Advanced Histology Spatial Analysis
- High-plex in situ subcellular resolution with nanometer precision.
- Diverse panel menu to fit any research need, from standard panels (50-5,000 genes) to custom panels. Advanced custom panel design for T- and B-cell receptors, SNVs, and isoforms is available.
- Powerful on-board analysis and free visualization software
- Suitable for FFPE or fresh frozen tissues.
Related projects: Xenium on sections from mouse and human bone
- High-plex analysis platform for spatial multiomics analysis.
- Compatible with formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF) tissue samples.
- Whole transcriptome profiling or/and 570+ protein antibody panel in one assay. (Possible to add customized gene or protein targets.)
- Flexibility and scalable, free selection of region of interest (ROI)s based on your knowledge.
Related projects: Human GeoMx study | Murine GeoMx study
3D Visualisation and Analysis
- High-resolution 3D imaging of large samples to ensure high image quality from overview to subcellular details.
- 1.1x, 4x, and 12x MI Plan objectives are available.
- Automated switching between different objectives, sample locations, and fluorescence channels with autofocus feature.
Related projects: Light sheet fluorescence microscopy project
Histology
High throughput Olympus Slide Scanner VS200
- Offer brightfield, polarization, fluorescence, dark field, and phase contrast modes.
- High optical resolution and image quality enable visual or automated analysis of image inforamtion.
- Enhanced z-focus with linear encoders results in higher re-adjustment accuracy.
Histology
- Tissue processing, sectioning, staining, scanning (digitalisation), and analysis
Bone Histomophometry
Bone histomophometry
- Histomophometry, micro CT for bone structure, bone biomechanics
Software
- HALO & HALO AI
- Imaris
- MACS iQ View
- Amira